Details

Autor(en) / Beteiligte

• Burgess, Stephen
• Davey Smith, George
• Davies, Neil M.
• Dudbridge, Frank
• Gill, Dipender
• Glymour, M. Maria
• Hartwig, Fernando P.
• Holmes, Michael V.
• Minelli, Cosetta
• Relton, Caroline L.
• Theodoratou, Evropi

Titel

Guidelines for performing Mendelian randomization investigations

Ist Teil von

• Wellcome open research, 2020-04, Vol.4, p.186

Ort / Verlag

London: Wellcome Trust Limited

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.