Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Helicobacter pylori infection and lactose intolerance increase expiratory hydrogen
Ist Teil von
EXCLI journal, 2022-01, Vol.21, p.426-435
Ort / Verlag
Germany: Leibniz Research Centre for Working Environment and Human Factors
Erscheinungsjahr
2022
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Infection with
(
) may cause dyspepsia and/or unexplained functional nonspecific, gastrointestinal complaints of the irritable bowel syndrome (IBS) spectrum. Hitherto, in
infected patients with symptoms of the IBS spectrum the occurrence of additional food intolerance/malabsorption is not evaluated. We used a retrospective analysis of charts from 548 patients who presented with gastrointestinal complaints of the irritable bowel syndrome spectrum. An enzyme-linked IgA immunosorbent assay or histologic evaluation of gastric mucosa were used to detect
infection. A hydrogen breath (H
) test was performed to evaluate fructose malabsorption (FM) and lactose intolerance (LIT). Serum diamine oxidase value of <10 U/ml and a response to a histamine-reduced diet was used to identify histamine intolerance (HIT). We found 293 patients infected with
, within these were 58
patients with LIT, 23
LIT patients with FM and 46
LIT patients with HIT. Additionally, 13
lactose- and histamine intolerance patients also had FM. The Kruskal Wallis test and pairwise comparison were used to analyze differences of the area under the curve of expiratory hydrogen. In lactose H
breath tests compared with LIT-only patients, LIT with
, LIT and
with HIT, LIT and
with FM showed significantly higher exhaled H
levels (p=0.022). Pairwise comparison demonstrated
infected patients with LIT exhaled more H
compared to LIT-only (p=0.029).
with lactose- and histamine intolerance, and
with lactose-, histamine intolerance and FM compared to
-only patients indicated a significantly higher occurrence of stomach pain during lactose H
breath tests (p=0.012 and p=0.005, respectively). We demonstrate that LIT patients with high expiratory H
levels in lactose breath tests may have
infection and possibly additional food intolerance/malabsorption. Subsequently, besides
eradication, a dietician is necessary for an individually tailored reduction- or exclusion diet of symptom triggering food components.