Details

Autor(en) / Beteiligte

• Paprckova, Darina
• Niederlova, Veronika
• Moudra, Alena
• Drobek, Ales
• Pribikova, Michaela
• Janusova, Sarka
• Schober, Kilian
• Neuwirth, Ales
• Michalik, Juraj
• Huranova, Martina
• Horkova, Veronika
• Cesnekova, Michaela
• Simova, Michaela
• Prochazka, Jan
• Balounova, Jana
• Busch, Dirk H.
• Sedlacek, Radislav
• Schwarzer, Martin
• Stepanek, Ondrej

Titel

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Ist Teil von

• Frontiers in immunology, 2022-10, Vol.13, p.1009198-1009198

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8 + T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naïve monoclonal CD8 + T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.