Details

Autor(en) / Beteiligte

• Molina, Jonathan J
• Kohler, Kurt N
• Gager, Christopher
• Andersen, Marissa J
• Wongso, Ellsa
• Lucas, Elizabeth R
• Paik, Andrew
• Xu, Wei
• Donahue, Deborah L
• Bergeron, Karla
• Klim, Aleksandra
• Caparon, Michael G
• Hultgren, Scott J
• Desai, Alana
• Ploplis, Victoria A
• Flick, Matthew J
• Castellino, Francis J
• Flores-Mireles, Ana L

Titel

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI

Ist Teil von

• Nature communications, 2024-03, Vol.15 (1), p.2704-2704, Article 2704

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2024

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens. Using our established mouse model of CAUTI, here we identified that host populations exhibiting either genetic or acquired fibrinolytic-deficiencies, inducing fibrin deposition in the catheterized bladder, are predisposed to severe CAUTI and septicemia by diverse uropathogens in mono- and poly-microbial infections. Furthermore, here we found that Enterococcus faecalis, a prevalent CAUTI pathogen, uses the secreted protease, SprE, to induce fibrin accumulation and create a niche ideal for growth, biofilm formation, and persistence during CAUTI.