Molecules (Basel, Switzerland), 2018-01, Vol.23 (2), p.286
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity
- Ist Teil von
- Molecules (Basel, Switzerland), 2018-01, Vol.23 (2), p.286
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection. Six chloro-1,4-dimethyl-9 -carbazoles ( , - , ) have been prepared following opportunely modified known chemical procedures and tested in luciferase and β-galactosidase expressing CD4⁺, CXCR4⁺, CCR5⁺ TZM-bl cells. a preliminary biological investigation on the synthesized small series of chloro-1,4-dimethyl-9 -carbazoles has been carried out. Among all tested compounds, a nitro-derivative ( ) showed the most interesting profile representing a suitable lead for the development of novel anti-HIV drugs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules23020286Titel-ID: cdi_doaj_primary_oai_doaj_org_article_3c8c44b5845d400abe33d76d93b5a0af
- Format
- –
- Schlagworte
- Anti-HIV Agents - chemical synthesis, Anti-HIV Agents - chemistry, Anti-HIV Agents - pharmacology, Antiviral activity, Antiviral agents, Biological effects, Carbazole, carbazole derivatives, Carbazoles, Carbazoles - chemical synthesis, Carbazoles - chemistry, Carbazoles - pharmacology, CCR5 protein, CD4 antigen, Cell Line, Chronic infection, Communication, CXCR4 protein, Disease transmission, Drug development, Drugs, Galactosidase, HIV, HIV Infections - genetics, HIV Infections - metabolism, HIV Infections - pathology, HIV Infections - prevention & control, Human immunodeficiency virus, Humans, Sexual transmission, Sexually transmitted diseases, Side effects, STD, Viruses, β-Galactosidase