Details

Autor(en) / Beteiligte

• Turchi, Riccardo
• Sciarretta, Francesca
• Ceci, Veronica
• Tiberi, Marta
• Audano, Matteo
• Pedretti, Silvia
• Panebianco, Concetta
• Nesci, Valentina
• Pazienza, Valerio
• Ferri, Alberto
• Carotti, Simone
• Chiurchiù, Valerio
• Mitro, Nico
• Lettieri-Barbato, Daniele
• Aquilano, Katia

Titel

Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich’s ataxia mouse model

Ist Teil von

• iScience, 2023-10, Vol.26 (10), p.107713, Article 107713

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Friedreich’s ataxia (FA) is a neurodegenerative disease resulting from a mutation in the FXN gene, leading to mitochondrial frataxin deficiency. FA patients exhibit increased visceral adiposity, inflammation, and heightened diabetes risk, negatively affecting prognosis. We investigated visceral white adipose tissue (vWAT) in a murine model (KIKO) to understand its role in FA-related metabolic complications. RNA-seq analysis revealed altered expression of inflammation, angiogenesis, and fibrosis genes. Diabetes-like traits, including larger adipocytes, immune cell infiltration, and increased lactate production, were observed in vWAT. FXN downregulation in cultured adipocytes mirrored vWAT diabetes-like features, showing metabolic shifts toward glycolysis and lactate production. Metagenomic analysis indicated a reduction in fecal butyrate-producing bacteria, known to exert antidiabetic effects. A butyrate-enriched diet restrained vWAT abnormalities and mitigated diabetes features in KIKO mice. Our work emphasizes the role of vWAT in FA-related metabolic issues and suggests butyrate as a safe and promising adjunct for FA management. [Display omitted] •VWAT of FA mice shows altered expression of inflammatory and angiogenic genes•FXN-lacking adipocytes rewire metabolism toward glycolysis and lactate production•FA mice exhibit gut dysbiosis with a reduced abundance of butyrate-producing bacteria•Dietary butyrate supplementation prevents vWAT alterations and glucose intolerance Pharmacology; Natural sciences; Biological sciences; Neuroscience