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Dogs can detect an odor profile associated with Staphylococcus aureus biofilms in cultures and biological samples
Ist Teil von
Frontiers in allergy, 2024-02, Vol.5, p.1275397-1275397
Ort / Verlag
Switzerland: Frontiers Media S.A
Erscheinungsjahr
2024
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
The study investigated the utilization of odor detection dogs to identify the odor profile of
biofilms in pure
samples and in
biosamples from animals and humans with
periprosthetic joint infection (PJI). Biofilms form when bacterial communities aggregate on orthopedic implants leading to recalcitrant infections that are difficult to treat. Identifying PJI biofilm infections is challenging, and traditional microbiological cultures may yield negative results even in the presence of clinical signs.
Dogs were trained on pure
biofilms and tested on lacrimal fluid samples from an
animal model (rabbits) and human patients with confirmed
PJI.
The results demonstrated that dogs achieved a high degree of sensitivity and specificity in detecting the odor profile associated with
biofilms in rabbit samples. Preliminary results suggest that dogs can recognize
volatile organic compounds (VOCs) in human lacrimal fluid samples.
Training odor detection dogs on
, may provide an alternative to obtaining clinical samples for training and mitigates biosecurity hazards. The findings hold promise for culture-independent diagnostics, enabling early disease detection, and improved antimicrobial stewardship. In conclusion, this research demonstrates that dogs trained on
samples can identify the consistent VOC profile of PJI
biofilm infections. The study opens avenues for further investigations into a retained VOC profile of
biofilm infection. These advancements could revolutionize infectious disease diagnosis and treatment, leading to better patient outcomes and addressing the global challenge of antimicrobial resistance.