Details

Autor(en) / Beteiligte

• Pashangzadeh, Salar
• Motallebnezhad, Morteza
• Vafashoar, Fatemeh
• Khalvandi, Azadeh
• Mojtabavi, Nazanin

Titel

Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases

Ist Teil von

• Frontiers in immunology, 2021-05, Vol.12, p.669382-669382

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2021

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• MicroRNAs (miRNAs) are small noncoding conserved RNAs containing 19 to 24 nucleotides that are regulators of post-translational modifications and are involved in the majority of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development. Autoimmune diseases are characterized by immune system dysregulation, which ultimately leads to destructive responses to self-antigens. A large body of literature suggests that autoimmune diseases and immune dysregulation are associated with different miRNA expression changes in the target cells and tissues of adaptive or innate immunity. miR-155 is identified as a critical modulator of immune responses. Recently conducted studies on the expression profile of miR-155 suggest that the altered expression and function of miR-155 can mediate vulnerability to autoimmune diseases and cause significant dysfunction of the immune system.