Details

Autor(en) / Beteiligte

• Yang, Liang
• Shen, Junfeng
• Liu, Chunhua
• Kuang, Zhonghua
• Tang, Yong
• Qian, Zhengjiang
• Guan, Min
• Yang, Yongfeng
• Zhan, Yang
• Li, Nan
• Li, Xiang

Titel

Nicotine rebalances NAD + homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

Ist Teil von

• Nature communications, 2023-02, Vol.14 (1), p.900-900, Article 900

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Imbalances in NAD homeostasis have been linked to aging and various diseases. Nicotine, a metabolite of the NAD metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here we find that, independent of nicotinic acetylcholine receptors, low-dose nicotine can restore the age-related decline of NAMPT activity through SIRT1 binding and subsequent deacetylation of NAMPT, thus increasing NAD synthesis. F-FDG PET imaging revealed that nicotine is also capable of efficiently inhibiting glucose hypermetabolism in aging male mice. Additionally, nicotine ameliorated cellular energy metabolism disorders and deferred age-related deterioration and cognitive decline by stimulating neurogenesis, inhibiting neuroinflammation, and protecting organs from oxidative stress and telomere shortening. Collectively, these findings provide evidence for a mechanism by which low-dose nicotine can activate NAD salvage pathways and improve age-related symptoms.