Nutrients, 2020-01, Vol.12 (1), p.130
2020
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- Autor(en) / Beteiligte
- Titel
- Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction
- Ist Teil von
- Nutrients, 2020-01, Vol.12 (1), p.130
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu12010130Titel-ID: cdi_doaj_primary_oai_doaj_org_article_3b2274294d7c4ceb919e0998459c341c
- Format
- –
- Schlagworte
- Animals, Antigens, Biological activity, Cell culture, condensed tannin, Cytokines, Endotoxins, Environmental factors, Enzymes, flavan-3-ol, flavonoid, gut, Health promotion, Homeostasis, Humans, ibd, Inflammation, Inflammation - drug therapy, Inflammatory bowel diseases, Inflammatory Bowel Diseases - diet therapy, Inflammatory Bowel Diseases - etiology, Intestine, Kinases, metabolic endotoxemia, Microbiota, Microorganisms, Molecular modelling, Mucosa, obesity, Obesity - complications, Pathogens, Peptides, permeability, Phosphorylation, Physiology, Phytochemicals, Proanthocyanidins, Proanthocyanidins - pharmacology, procyanidin, Proteins, Regulation, Review, Seeds, Tumor necrosis factor-TNF