Details

Autor(en) / Beteiligte

• Viddeleer, Alain R.
• Raaphorst, Joost
• Min, Minoesch
• Beenen, Ludo F.M.
• Scheerder, Maeke J.
• Vlaar, Alexander P.J.
• Beudel, Martijn
• Hemke, Robert
• Bruin, Sanne
• Schuurmans, Alex
• Koning, Rutger
• Agtmael, Michiel
• Algera, Anne Geke
• Baarle, Frank
• Bax, Diane
• Bogaard, Harm Jan
• Bomers, Marije
• Bonta, Peter
• Bos, Lieuwe
• Botta, Michela
• Brabander, Justin
• Bree, Godelieve
• Bugiani, Marianna
• Bulle, Esther
• Chouchane, Osoul
• Cloherty, Alex
• Dongelmans, Dave A.
• Elbers, Paul
• Fleuren, Lucas
• Geerlings, Suzanne
• Geerts, Bart
• Geijtenbeek, Theo
• Girbes, Armand
• Goorhuis, Bram
• Grobusch, Martin P.
• Hafkamp, Florianne
• Hagens, Laura
• Hamann, Jorg
• Harris, Vanessa
• Hermans, Sabine M.
• Heunks, Leo
• Hollmann, Markus
• Horn, Janneke
• Hovius, Joppe W.
• Jong, Menno D.
• Mourik, Niels
• Nossent, Esther J.
• Nellen, Jeaninne
• Paulus, Frederique
• Reijnders, Tom
• Peters, Edgar
• Poll, Tom
• Preckel, Bennedikt
• Prins, Jan M.
• Raasveld, Jorinde
• Schinkel, Michiel
• Schultz, Marcus J.
• Sigaloff, Kim
• Smit, Marry
• Stijnis, Cornelis S.
• Stilma, Willemke
• Teunissen, Charlotte
• Thoral, Patrick
• Tsonas, Anissa
• Valk, Marc
• Veelo, Denise
• Vries, Heder
• Vugt, Michèle
• Wouters, Dorien
• Zwinderman, A. H (Koos)
• Brouwer, Matthijs C.
• Wiersinga, W. Joost
• Beek, Diederik

Titel

Intramuscular adipose tissue at level Th12 is associated with survival in COVID‐19

Ist Teil von

• Journal of cachexia, sarcopenia and muscle, 2021-06, Vol.12 (3), p.823-827

Ort / Verlag

Germany: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• Sarcopenia, as an example of abnormal body composition, is defined as a significant loss of skeletal muscle mass (muscle wasting) and muscle strength and infiltration of muscle by fat and connective tissue. 1,2 Body composition has been studied using a single computed tomography (CT) slice, which is considered the reference standard for quantitative body composition studies. 3,4 Abnormal body composition, and in particular sarcopenia, has been associated with survival in patients with cancer 5 or an increased cardiometabolic risk. 6 Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused a pandemic of coronavirus disease 19 (COVID‐19). Inclusion criteria were a polymerase chain reaction‐confirmed COVID‐19 infection, age ≥18 years, need for hospitalization, availability of a CT scan of the chest and availability of clinical outcome data. 1 TablePatient characteristics of COVID‐19 patients based on outcome after 3 weeks of admission Dead Alive P‐value Clinical feature n = 40 n = 175 No. (%) of female patients 13 (32.5%) 73 (41.7%) 0.371 a Age at admission 66.9 (12.0) 59.8 (14.5) 0.004 Length (cm) 172.0 (11.7) 171.8 (9.7) 0.948 Weight (kg) 86.5 (18.8) 85.4 (18.5) 0.760 Body mass index 29.0 (5.8) 28.8 (6.2) 0.841 Clinical outcome measures No. (%) of patients admitted to MCU/ICU 24 (60.0%) 34 (19.4%) <0.001 a No. (%) of patients with oxygen therapy 39 (97.5%) 153 (87.4%) 0.086 a No. (%) of patients with non‐invasive ventilation b 4 (10.0%) 12 (6.9%) 0.506 a No. (%) of patients with invasive ventilation 22 (55.0%) 34 (19.4%) <0.001 a Duration of invasive ventilation, median days (median, IQR) c 10.0 (7.8–13.0) 14.0 (7.5–21.8) 0.046 Body composition measures Muscle cross section area (cm2), median (IQR) c 104.0 (83.3–116.7) 108.0 (86.5–124.4) 0.704 Skeletal muscle index (cm2/m2) 35.7 (9.5) 36.1 (9.1) 0.820 Muscle density (HU) c 24.0 (10.1) 27.6 (10.9) 0.067 IMAT cross sectional area (cm2), median (IQR) c 10.1 (5.0–18.0) 6.2 (3.7–11.4) 0.009 IMAT index (cm2/m2), median (IQR) c 3.6 (1.6–8.1) 2.1 (1.2–3.9) 0.013 SAT cross‐sectional area (cm2), median (IQR) c 160.4 (115.7–198.8) 133.1 (97.9–190.6) 0.219 SAT index (cm2/m2), median (IQR) c 52.6 (35.1–79.7) 41.7 (31.3–68.7) 0.193 Scores are presented as mean (SD), except where stated otherwise. [...]we can only speculate on mechanisms explaining how fatty muscle degeneration at the low thoracic level leads to lower survival, which may include respiratory muscle impairment (e.g. ineffective cough leading to more progressive pulmonary disease).