Details

Autor(en) / Beteiligte

• Ramirez, Julio A
• Angulo, Frederick J
• Carrico, Ruth M
• Furmanek, Stephen
• Oliva, Senen Pena
• Zamparo, Joann M
• Gonzalez, Elisa
• Zhang, Pingping
• Parrish, Leslie A. Wolf
• Marimuthu, Subathra
• Pride, Michael W
• Gray, Sharon
• Ferreira, Catia S. Matos
• Arnold, Forest W
• Isturiz, Raul E
• Minarovic, Nadia
• Moisi, Jennifer C
• Jodar, Luis

Titel

Misdiagnosis of Clostridioides difficile Infections by Standard-of-Care Specimen Collection and Testing among Hospitalized Adults, Louisville, Kentucky, USA, 2019-2020

Ist Teil von

• Emerging infectious diseases, 2023-05, Vol.29 (5), p.919-928

Ort / Verlag

Atlanta: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Although Clostridioides difficile infection (CDI) incidence is high in the United States, standard-of-care (SOC) stool collection and testing practices might result in incidence overestimation or underestimation. We conducted diarrhea surveillance among inpatients >50 years of age in Louisville, Kentucky, USA, during October 14, 2019–October 13, 2020; concurrent SOC stool collection and CDI testing occurred independently. A study CDI case was nucleic acid amplification test‒/cytotoxicity neutralization assay‒positive or nucleic acid amplification test‒positive stool in a patient with pseudomembranous colitis. Study incidence was adjusted for hospitalization share and specimen collection rate and, in a sensitivity analysis, for diarrhea cases without study testing. SOC hospitalized CDI incidence was 121/100,000 population/year; study incidence was 154/100,000 population/year and, in sensitivity analysis, 202/100,000 population/year. Of 75 SOC CDI cases, 12 (16.0%) were not study diagnosed; of 109 study CDI cases, 44 (40.4%) were not SOC diagnosed. CDI incidence estimates based on SOC CDI testing are probably underestimated.