Details

Autor(en) / Beteiligte

• Un, Sovannary
• Quan, Nguyen Van
• Anh, La Hoang
• Lam, Vu Quang
• Takami, Akiyoshi
• Khanh, Tran Dang
• Xuan, Tran Dang

Titel

Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials of Sargassum spp

Ist Teil von

• Molecules (Basel, Switzerland), 2022-04, Vol.27 (7), p.2307

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• This is the first study to examine the effects of in vitro digestion on biological activities of spp., a broadly known brown seaweed for therapeutic potential. Three fractions (F1-F3) were obtained from hexane extract by column chromatography. Under in vitro simulated digestion, the anti-α-amylase capacity of F1 in oral and intestinal phases increases, while it significantly decreases in the gastric phase. The α-amylase inhibition of F2 promotes throughout all digestive stages while the activity of F3 significantly reduces. The cytotoxic activity of F1 against U266 cell-line accelerates over the oral, gastric, and intestinal stages. The fractions F2 and F3 exhibited the declined cytotoxic potentialities in oral and gastric phases, but they were strengthened under intestinal condition. Palmitic acid and fucosterol may play an active role in antidiabetic and cytotoxic activity against multiple myeloma U266 cell line of spp. However, the involvement of other phytochemicals in the seaweed should be further investigated.