Details

Autor(en) / Beteiligte

• Chang, Bin
• Tamura, Kosuke
• Fujikura, Hiroyuki
• Watanabe, Hiroshi
• Tanabe, Yoshinari
• Kuronuma, Koji
• Fujita, Jiro
• Oshima, Kengo
• Maruyama, Takaya
• Abe, Shuichi
• Kasahara, Kei
• Nishi, Junichiro
• Kubota, Tetsuya
• Kinjo, Yuki
• Serizawa, Yusuke
• Shimbashi, Reiko
• Fukusumi, Munehisa
• Shimada, Tomoe
• Sunagawa, Tomimasa
• Suzuki, Motoi
• Oishi, Kazunori

Titel

Pneumococcal meningitis in adults in 2014–2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan

Ist Teil von

• Scientific reports, 2022-02, Vol.12 (1), p.3066-3066, Article 3066

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population . Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1b A641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).