Nature communications, 2019-12, Vol.10 (1), p.5695-15, Article 5695
2019
Details
- Autor(en) / Beteiligte
- Titel
- Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
- Ist Teil von
- Nature communications, 2019-12, Vol.10 (1), p.5695-15, Article 5695
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced by external factors such as tissues microenvironment or host microbiota. Here we used high throughput metabolomics to analyze two cohorts of genotypically HLA-identical related recipient and donor pairs. Metabolomic profiles markedly differ between recipients and donors. At the onset of acute GvHD, in addition to host-derived metabolites, we identify significant variation in microbiota-derived metabolites, especially in aryl hydrocarbon receptor (AhR) ligands, bile acids and plasmalogens. Altogether, our findings support that the allogeneic immune response during acute GvHD might be influenced by bile acids and by the decreased production of AhR ligands by microbiota that could limit indoleamine 2,3-dioxygenase induction and influence allogeneic T cell reactivity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-019-13498-3Titel-ID: cdi_doaj_primary_oai_doaj_org_article_3747dae6cbe941c7a74462b4f4f93fd1
- Format
- –
- Schlagworte
- Acute Disease, Adult, Aged, Bile Acids and Salts, Bile Acids and Salts - analysis, Bile Acids and Salts - immunology, Bile Acids and Salts - metabolism, Case-Control Studies, Cohort Studies, Female, Gastrointestinal Microbiome, Gastrointestinal Microbiome - physiology, Graft vs Host Disease, Graft vs Host Disease - blood, Graft vs Host Disease - etiology, Graft vs Host Disease - metabolism, Graft-versus-host reaction, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation - adverse effects, Hematopoietic Stem Cell Transplantation - methods, Hematopoietic stem cells, Humans, Immunology, Life Sciences, Ligands, Living Donors, Male, Metabolites, Metabolome, Metabolome - immunology, Metabolomics, Metabolomics - methods, Microbiota, Middle Aged, Plasmalogens, Plasmalogens - analysis, Plasmalogens - immunology, Plasmalogens - metabolism, Receptors, Aryl Hydrocarbon, Receptors, Aryl Hydrocarbon - immunology, Receptors, Aryl Hydrocarbon - metabolism, Siblings, Stem cell transplantation, Stem cells, T-Lymphocytes, T-Lymphocytes - immunology, Transplantation, Transplantation, Homologous, Transplantation, Homologous - adverse effects, Transplantation, Homologous - methods, Transplants & implants, Tryptophan, Tryptophan - immunology, Tryptophan - metabolism, Young Adult