Details

Autor(en) / Beteiligte

• Sinha, Shubhadeep D
• Bandi, Vamsi Krishna
• Bheemareddy, Bala Reddy
• Thakur, Pankaj
• Chary, Sreenivasa
• Mehta, Kalpana
• Pinnamareddy, Vikranth Reddy
• Pandey, Rajendra
• Sreepada, Subhramanyam
• Durugkar, Santosh

Titel

Efficacy, tolerability and safety of darbepoetin alfa injection for the treatment of anemia associated with chronic kidney disease (CKD) undergoing dialysis: a randomized, phase-III trial

Ist Teil von

• BMC nephrology, 2019-03, Vol.20 (1), p.90-9, Article 90

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2019

Quelle

SpringerLink

Beschreibungen/Notizen

• Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein which has half-life three-fold longer than that of Erythropoietin alfa (EPO). The objective of this study was to compare the efficacy and safety of DA-α injection versus EPO for treating renal anemia amongst Indian patients with end-stage renal disease (ESRD) undergoing dialysis. Patients of either gender (aged 18-65 years) with ESRD undergoing dialysis who had hemoglobin (Hb) levels < 10 g/dL after receiving EPO were switched to DA-α (0.45 μg/kg) once weekly subcutaneously or EPO 50 IU/kg thrice weekly subcutaneously (centrally randomized 1:1) for 12-24 weeks (correction phase) followed by 12 weeks maintenance phase (for Hb levels ≥10 g/dL). The primary efficacy endpoint was mean change in Hb level from baseline to end of correction phase. In the intention-to-treat population (n = 126), the between group difference in mean Hb change was - 0.01 g/dL (95% CI - 0.68 to - 0.66, p = 0.97). After adjusting for covariates, the difference was - 0.2878 g/dL (95% CI -0.936 to0.360). The lower limit of the two-sided 95% CI of primary endpoint was above the pre-specified non-inferiority margin of - 1.0 g/dL. Similar trend of non-inferiority was observed for per-protocol population. Safety profile of DA-α and EPO were observed to be similar. Our study results demonstrated that for patients with ESRD undergoing dialysis, administering DA-α at lower dose frequency, is equally effective and well tolerated as EPO for treating renal anemia. CTRI/2012/07/002835 [Registered on: 27/07/2012]; Trial Registered Prospectively.