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Genomic Analysis of Sphingopyxis sp. USTB-05 for Biodegrading Cyanobacterial Hepatotoxins
Ist Teil von
Toxins, 2022-05, Vol.14 (5), p.333
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
sp. USTB-05, which we previously identified and examined, is a well-known bacterial strain for biodegrading cyanobacterial hepatotoxins of both nodularins (NODs) and microcystins (MCs). Although the pathways for biodegrading the different types of [D-Asp
] NOD, MC-YR, MC-LR and MC-RR by
sp. USTB-05 were suggested, and several biodegradation genes were successfully cloned and expressed, the comprehensive genomic analysis of
sp. USTB-05 was not reported. Here, based on second and third generation sequencing technology, we analyzed the whole genome of
sp. USTB-05, which is 4,679,489 bp and contains 4,312 protein coding genes. There are 88 protein-coding genes related to the NODs and MCs biodegradation, of which 16 genes (
,
,
,
,
,
,
,
,
,
,
,
,
,
,
and
) are unique. These genes for the transformation of phenylacetic acid CoA (PA-CoA) to CO
were also found in
sp. USTB-05. This study expands the understanding of the pathway for complete biodegradation of cyanobacterial hepatotoxins by
sp. USTB-05.