Details

Autor(en) / Beteiligte

• Boutin, Rozlyn Ct
• Petersen, Charisse
• Woodward, Sarah E
• Serapio-Palacios, Antonio
• Bozorgmehr, Tahereh
• Loo, Rachelle
• Chalanuchpong, Alina
• Cirstea, Mihai
• Lo, Bernard
• Huus, Kelsey E
• Barcik, Weronika
• Azad, Meghan B
• Becker, Allan B
• Mandhane, Piush J
• Moraes, Theo J
• Sears, Malcolm R
• Subbarao, Padmaja
• McNagny, Kelly M
• Turvey, Stuart E
• Finlay, B Brett

Titel

Bacterial-fungal interactions in the neonatal gut influence asthma outcomes later in life

Ist Teil von

• eLife, 2021-04, Vol.10

Ort / Verlag

England: eLife Sciences Publications Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Bacterial members of the infant gut microbiota and bacterial-derived short-chain fatty acids (SCFAs) have been shown to be protective against childhood asthma, but a role for the fungal microbiota in asthma etiology remains poorly defined. We recently reported an association between overgrowth of the yeast in the gut microbiota of Ecuadorian infants and increased asthma risk. In the present study, we replicated these findings in Canadian infants and investigated a causal association between early life gut fungal dysbiosis and later allergic airway disease (AAD). In a mouse model, we demonstrate that overgrowth of within the neonatal gut exacerbates features of type-2 and -17 inflammation during AAD later in life. We further show that growth and adherence to gut epithelial cells are altered by SCFAs. Collectively, our results underscore the potential for leveraging inter-kingdom interactions when designing putative microbiota-based asthma therapeutics.