Details

Autor(en) / Beteiligte

• Lei, Xinyuan
• Lin, Hsinyu
• Wang, Jieqi
• Ou, Zhanpeng
• Ruan, Yi
• Sadagopan, Ananthan
• Chen, Weixiong
• Xie, Shule
• Chen, Baisheng
• Li, Qunxing
• Wang, Jue
• Lin, Huayue
• Zhu, Xiaofeng
• Yuan, Xiaoqing
• Tian, Tian
• Lv, Xiaobin
• Fu, Sha
• Zhu, Xiaorui
• Zhou, Jian
• Pan, Guokai
• Xia, Xin
• Tannous, Bakhos A
• Ferrone, Soldano
• Fan, Song
• Li, Jinsong

Titel

Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Ist Teil von

• Nature communications, 2022-07, Vol.13 (1), p.3882-3882, Article 3882

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP-1s is a transcription factor for aminopeptidase TPP2, which inhibits MHC-I complex cell surface expression likely by degrading tumor antigen peptides. Mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell therapy in patient-derived tumor models. Therefore mitochondrial fission inhibition might provide an approach to enhance the efficacy of T cell-based immunotherapy.