Neurobiology of disease, 2003-12, Vol.14 (3), p.349-356
2003
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- Autor(en) / Beteiligte
- Titel
- Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
- Ist Teil von
- Neurobiology of disease, 2003-12, Vol.14 (3), p.349-356
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0969-9961eISSN: 1095-953XDOI: 10.1016/S0969-9961(03)00107-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_34e1ff2b1c2c42ea8e9748eda01ac032
- Format
- –
- Schlagworte
- Alzheimer's disease, Animals, Annexin A5 - metabolism, Apoptosis, Apoptosis - genetics, Brain - metabolism, Brain - pathology, Brain - physiopathology, Caspase 3, Caspases - metabolism, Cells, Cultured, Chromosomes, Human, Pair 21 - genetics, DNA-Binding Proteins, Down syndrome, Down Syndrome - genetics, Down Syndrome - metabolism, Ets transcription factor, Ets2, Fetus, Gene Expression Regulation - genetics, Humans, Mice, Mice, Transgenic, Neurodegenerative Diseases - genetics, Neurodegenerative Diseases - metabolism, Neurons - metabolism, Neurons - pathology, Proto-Oncogene Protein c-ets-2, Proto-Oncogene Proteins - genetics, Proto-Oncogene Proteins - metabolism, Repressor Proteins, Trans-Activators - genetics, Trans-Activators - metabolism, Transcription Factors, Up-Regulation - genetics, β-APP