Molecules (Basel, Switzerland), 2012-07, Vol.17 (7), p.8494-8505
2012
Details
- Autor(en) / Beteiligte
- Titel
- Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle
- Ist Teil von
- Molecules (Basel, Switzerland), 2012-07, Vol.17 (7), p.8494-8505
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Ischemia-reperfusion (IR) can lead to serious tissue oxidative injury in animals. ShuJinHuoXue tablet (SJHXT) is a Chinese Traditional Medicine which can relax the muscles and stimulate the blood circulation and has been used as a clinical medicine. In the present study, we investigated the effects of SJHXT pretreatment on oxidative injury using an animal model of acute limb IR. Results showed that SJHXT pre-treatment (200, 300 and 400 mg/kg/day) markedly reduced serum endothelin-1 (ET-1), thromboxane B2 (TXB₂) levels and thromboxane B2/6-keto- prostaglandin F1α (TXB₂/6-Keto-PGF(1α)), wet weight/dried weight (W/D) ratio, myeloperoxidase (MPO), creatine kinase (CK), lactate dehydrogenase (LDH) activities, and increased serum nitric oxide (NO), 6-Keto-PGF(1α) levels and NO/ET-1 ratio in the IR+SJHXT groups. In addition, the SJHXT pre-treatment (200, 300 and 400 mg/kg/day) markedly reduced skeletal muscle Ca²⁺, malondialdehyde (MDA) levels, increased Na⁺-K⁺-ATPase, Ca²⁺-Mg²⁺-ATPase, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. Our results suggest that SJHXT pre-treatment may improve skeletal muscle blood vessel microcirculation, decrease skeletal muscle oxidative injury and enhance antioxidant enzymes activities in IR animals.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules17078494Titel-ID: cdi_doaj_primary_oai_doaj_org_article_34b8dd3db16c405ca112e0ff5f7d111d
- Format
- –
- Schlagworte
- Animals, antioxidant, Ca(2+) Mg(2+)-ATPase - metabolism, Catalase - metabolism, Creatine Kinase - blood, Drugs, Chinese Herbal - pharmacology, Drugs, Chinese Herbal - therapeutic use, Endothelin-1 - blood, GSH-Px, L-Lactate Dehydrogenase - blood, Malondialdehyde - metabolism, Muscle, Skeletal - blood supply, Muscle, Skeletal - drug effects, Muscle, Skeletal - enzymology, Muscle, Skeletal - pathology, Nitric Oxide - blood, Peroxidase - blood, Phytotherapy, Prostaglandins F - blood, Rabbits, Reperfusion Injury - blood, Reperfusion Injury - drug therapy, Reperfusion Injury - enzymology, Reperfusion Injury - pathology, ShuJinHuoXue tablets, SOD, Sodium-Potassium-Exchanging ATPase - metabolism, Superoxide Dismutase - metabolism, Tablets, Thromboxane B2 - blood