Details

Autor(en) / Beteiligte

• Xiong, Yuguang
• Liu, Tong
• Chen, Tong
• Hansen, Jens
• Hu, Bin
• Chen, Yibang
• Jayaraman, Gomathi
• Schürer, Stephan
• Vidovic, Dusica
• Goldfarb, Joseph
• Sobie, Eric A.
• Birtwistle, Marc R.
• Iyengar, Ravi
• Li, Hong
• Azeloglu, Evren U.

Titel

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity

Ist Teil von

• Scientific data, 2022-01, Vol.9 (1), p.18-11, Article 18

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers for the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. Its key aim is to generate proteomic and transcriptomic signatures that can predict cardiotoxic adverse effects of kinase inhibitors approved by the Food and Drug Administration. Towards this goal, high throughput shotgun proteomics experiments (308 cell line/drug combinations +64 control lysates) have been conducted. Using computational network analyses, these proteomic data can be integrated with transcriptomic signatures, generated in tandem, to identify cellular signatures of cardiotoxicity that may predict kinase inhibitor-induced toxicity and enable possible mitigation. Both raw and processed proteomics data have passed several quality control steps and been made publicly available on the PRIDE database. This broad protein kinase inhibitor-stimulated human cardiomyocyte proteomic data and signature set is valuable for prediction of drug toxicities. Measurement(s) protein expression profiling Technology Type(s) mass spectrometry assay Factor Type(s) Individual proteome • Kinase inhibitors Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.16990033