PLoS pathogens, 2024-01, Vol.20 (1), p.e1011895-e1011895
2024
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- Autor(en) / Beteiligte
- Titel
- Function and mechanism of TREM2 in bacterial infection
- Ist Teil von
- PLoS pathogens, 2024-01, Vol.20 (1), p.e1011895-e1011895
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2024
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Triggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-mediated inhibition of inflammation by negatively regulating the Toll-like receptor (TLR) response. We further illustrate the role of TREM2 in restoring organ homeostasis in sepsis and soluble TREM2 (sTREM2) as a diagnostic marker for sepsis-associated encephalopathy (SAE). Finally, we discuss the prospect of TREM2 as an interesting therapeutic target for sepsis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7374, 1553-7366eISSN: 1553-7374DOI: 10.1371/journal.ppat.1011895Titel-ID: cdi_doaj_primary_oai_doaj_org_article_33fcb1f5fffa482a93667b01d0359dec
- Format
- –
- Schlagworte
- Analysis, Apolipoproteins, Bacteria, Bacterial diseases, Bacterial infections, Bacterial Infections - metabolism, Biology and Life Sciences, Care and treatment, Cytokines, Dendritic cells, Disease, E coli, Encephalopathy, Gene mutations, Health aspects, Homeostasis, Humans, Infections, Inflammation, Inflammation - metabolism, Kinases, Ligands, Lipids, Medicine and Health Sciences, Membrane Glycoproteins - metabolism, Microglia - metabolism, Microorganisms, Mutation, Myeloid cells, Nervous system, Pathogens, Phagocytosis, Phosphorylation, Prevention, Proteins, Receptors, Immunologic - metabolism, Research and Analysis Methods, Review, Risk factors, Sepsis, Sepsis - metabolism, Signal Transduction - physiology, Therapeutic targets, Toll-like receptors, Toll-Like Receptors - metabolism