Details

Autor(en) / Beteiligte

• Grueschow, Marcus
• Stenz, Nico
• Thörn, Hanna
• Ehlert, Ulrike
• Breckwoldt, Jan
• Brodmann Maeder, Monika
• Exadaktylos, Aristomenis K
• Bingisser, Roland
• Ruff, Christian C
• Kleim, Birgit

Titel

Real-world stress resilience is associated with the responsivity of the locus coeruleus

Ist Teil von

• Nature communications, 2021-04, Vol.12 (1), p.2275-17, Article 2275

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.