Details

Autor(en) / Beteiligte

• Radoshevich, Lilliana
• Dussurget, Olivier

Titel

Cytosolic Innate Immune Sensing and Signaling upon Infection

Ist Teil von

• Frontiers in microbiology, 2016-03, Vol.7, p.313-313

Ort / Verlag

Switzerland: Frontiers Media

Erscheinungsjahr

2016

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.