Genomics, proteomics & bioinformatics, 2016-02, Vol.14 (1), p.42-54
2016
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- Autor(en) / Beteiligte
- Titel
- Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
- Ist Teil von
- Genomics, proteomics & bioinformatics, 2016-02, Vol.14 (1), p.42-54
- Ort / Verlag
- China: Elsevier Ltd
- Erscheinungsjahr
- 2016
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Long non-coding RNAs （ineRNAs） play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a vari- ety of chromatin-based mechanisms and via cross-talk with other RNA species, lncRNAs can func- tion as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identi- fying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1672-0229eISSN: 2210-3244DOI: 10.1016/j.gpb.2015.09.006Titel-ID: cdi_doaj_primary_oai_doaj_org_article_31ca6c1c43344b06ba200ba9285dc248
- Format
- –
- Schlagworte
- Antisense oligonucleotides, Cancer, Chromatin, Chromatin - chemistry, Chromatin - metabolism, Chromatin Assembly and Disassembly, Gene Expression Regulation, Humans, lncRNAs, MicroRNAs - antagonists & inhibitors, MicroRNAs - genetics, MicroRNAs - metabolism, Neoplasms - genetics, Neoplasms - pathology, Oligonucleotides, Antisense - metabolism, Review, RNA, Long Noncoding - antagonists & inhibitors, RNA, Long Noncoding - genetics, RNA, Long Noncoding - metabolism, Transcription regulation, 反义寡核苷酸, 工作机制, 染色质重塑, 癌症, 社会机制, 转录后调控, 非编码RNA