Details

Autor(en) / Beteiligte

• Ng, Rita Wai-Yin
• Wong, Chun-Kwok
• Lui, Grace Chung-Yan
• Tso, Eugene Yuk-Keung
• Chen, Zigui
• Tsang, Owen Tak-Yin
• Boon, Siaw Shi
• Lai, Christopher Koon-Chi
• Fung, Kitty Sau-Chun
• Yeung, Apple Chung-Man
• Ho, Wendy Ching-Sze
• Hui, David Shu-Cheong
• Chan, Paul Kay-Sheung
• Chan, Jacky Man-Chun

Titel

Case series of HIV SARS-CoV-2 co-infection in Chinese adults

Ist Teil von

• Journal of clinical virology plus, 2022-02, Vol.2 (1), p.100062-100062, Article 100062

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •HIV and SARS-CoV-2 coinfection in Chinese adults.•Virus shedding and cytokines of 4 coinfected cases and 20 HIV-negative controls.•HIV patients had similar respiratory shedding but lower IL-10 and NT-pro-BNP levels.•All 4 PLWH patients had SARS-CoV-2 detected from faecal samples.•Faecal shedding duration of patient A, B, C and D were at least 9, 10, 33, 11 days Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong. PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed. HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset. PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.