Details

Autor(en) / Beteiligte

• Meirson, Tomer
• Nardone, Valerio
• Pentimalli, Francesca
• Markel, Gal
• Bomze, David
• D'Apolito, Maria
• Correale, Pierpaolo
• Giordano, Antonio
• Pirtoli, Luigi
• Porta, Camillo
• Gray, Steven G
• Mutti, Luciano

Titel

Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology

Ist Teil von

• Journal of translational medicine, 2022-12, Vol.20 (1), p.593-593, Article 593

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• In this commentary, using existing clinical trial data and FDA approvals we propose that there is currently a critical need for an appropriate balancing between the financial impact of new cancer drugs and their actual benefit for patients. By adopting "pleural mesothelioma" as our clinical model we summarize the most relevant pertinent and available literature on this topic, and use an analysis of the reliability of the trials submitted for registration and/or recently published as a case in point to raise concerns with respect to appropriate trial design, biomarker based stratification and to highlight the ongoing need for balancing the benefit/cost ratio for both patients and healthcare providers.