Details

Autor(en) / Beteiligte

• Papazian-Cabanas, Rodrigo M
• Araújo, Eduardo J A
• Silva, Aristeu V da
• Sant'Ana, Débora M G

Titel

Myenteric neuronal plasticity induced by Toxoplasma gondii (genotype III) on the duodenum of rats

Ist Teil von

• Anais da Academia Brasileira de Ciências, 2012-09, Vol.84 (3), p.737-746

Ort / Verlag

Brazil: Academia Brasileira de Ciências

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• The effects of acute and chronic infection caused by Toxoplasma gondii on duodenal myenteric neurons were analyzed. Eighteen rats were assigned into four groups: Acute Control Group (ACG, n=4); Acute Experimental Group (AEG, n=4); Chronic Control Group (CCG, n=5); and Chronic Experimental Group (CEG, n=5). Rats from the AEG and CEG were inoculated orally with 105 genotype III (BTU-II strain) tachyzoites of T. gondii isolated from a dog with neurological signs. Acute groups were killed after 24 hours after the inoculation and the chronic groups after 30 days. Whole-mount from the duodenum were stained with Giemsa. The population density of myenteric neurons, as well the body cell, nuclear and cytoplasmic area were analyzed. Both acute and chronic toxoplasmic infection did not provoke neuronal loss. On the other hand, plastic alterations were observed: decreasing of the nuclear and cytoplasmic area during the acute phase and neuronal hypertrophy during the chronic phase.