BMC cardiovascular disorders, 2021-08, Vol.21 (1), p.384-384, Article 384
2021
Details
- Autor(en) / Beteiligte
- Titel
- Demographic, clinical, and functional determinants of antithrombotic treatment in patients with nonvalvular atrial fibrillation
- Ist Teil von
- BMC cardiovascular disorders, 2021-08, Vol.21 (1), p.384-384, Article 384
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- 2022 ECC(Springer)
- Beschreibungen/Notizen
- This study assessed the sociodemographic, functional, and clinical determinants of antithrombotic treatment in patients with nonvalvular atrial fibrillation (NVAF) attended in the internal medicine setting. A multicenter, cross-sectional study was conducted in NVAF patients who attended internal medicine departments for either a routine visit (outpatients) or hospitalization (inpatients). A total of 961 patients were evaluated. Their antithrombotic management included: no treatment (4.7%), vitamin K antagonists (VKAs) (59.6%), direct oral anticoagulants (DOACs) (21.6%), antiplatelets (6.6%), and antiplatelets plus anticoagulants (7.5%). Permanent NVAF and congestive heart failure were associated with preferential use of oral anticoagulation over antiplatelets, while intermediate-to high-mortality risk according to the PROFUND index was associated with a higher likelihood of using antiplatelet therapy instead of oral anticoagulation. Longer disease duration and institutionalization were identified as determinants of VKA use over DOACs. Female gender, higher education, and having suffered a stroke determined a preferential use of DOACs. This real-world study showed that most elderly NVAF patients received oral anticoagulation, mainly VKAs, while DOACs remained underused. Antiplatelets were still offered to a proportion of patients. Longer duration of NVAF and institutionalization were identified as determinants of VKA use over DOACs. A poor prognosis according to the PROFUND index was identified as a factor preventing the use of oral anticoagulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-2261eISSN: 1471-2261DOI: 10.1186/s12872-021-02019-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_312ccfad72694f28a196a8788edf3892
- Format
- –
- Schlagworte
- Administration, Oral, Aged, Aged, 80 and over, Ambulatory Care, Antagonists, Anticoagulants, Anticoagulants - therapeutic use, Antithrombotic treatment, Atrial fibrillation, Atrial Fibrillation - complications, Cardiac arrhythmia, Care and treatment, Clinical medicine, Cognition Disorders - complications, Cognitive ability, Comorbidity, Congestive heart failure, Cross-Sectional Studies, Diagnosis, Direct-acting oral anticoagulants (DOACs), Disease prevention, Dosage and administration, Drug Therapy, Combination, Education, Educational Status, Factor Xa Inhibitors - therapeutic use, Female, Fibrillation, Hospitals, Humans, Internal medicine, Life expectancy, Male, Medicine, Morbidity, Mortality, Nonvalvular atrial fibrillation (NVAF), Patients, Platelet Aggregation Inhibitors - therapeutic use, Prognosis, Questionnaires, Spain, Stroke, Stroke - etiology, Stroke - prevention & control, Thromboembolism, Thrombolytic drugs, Vitamin K, Vitamin K antagonists (VKAs), Watchful Waiting - statistics & numerical data