Nutrients, 2020-01, Vol.12 (2), p.347
2020
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- Autor(en) / Beteiligte
- Titel
- Galangin Protects against Symptoms of Dextran Sodium Sulfate-induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota
- Ist Teil von
- Nutrients, 2020-01, Vol.12 (2), p.347
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed to investigate the preventive effects of galangin against dextran sulphate sodium (DSS)-induced acute murine colitis, which mimics the symptoms of human ulcerative colitis (UC). Pre-treatment with galangin (15 mg/kg, ) resulted in a significant decreased in the macroscopic signs of DSS-induced colitic symptoms, including a decreased disease activity index, prevention of the colon length shortening, and alleviation of the pathological changes occurring in the colon. Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group. Moreover, galangin pre-treatment significantly increased the expressions of autophagy-related proteins and promoted the formation of autophagosome in the colon. Galangin pre-treatment increased the diversity of the gut microbiota, and this was accompanied by increased levels of short-chain fatty acids. These observed changes could involve the modulating effects conferred by galangin in relation to some specific bacteria populations, including the recovery of spp., and increased spp. Overall, these results support the use of galangin in the prevention of UC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu12020347Titel-ID: cdi_doaj_primary_oai_doaj_org_article_30790c6f7be344c19b0be35fb22510e3
- Format
- –
- Schlagworte
- Animals, Autophagy, Autophagy - drug effects, Binding sites, Colitis - chemically induced, Colitis - prevention & control, Colon, Cytokines, Deoxyribonucleic acid, Dextran, Dextran Sulfate - toxicity, Disease, DNA, Drinking water, Flavonoids, Flavonoids - chemistry, Flavonoids - pharmacology, galangin, Gastrointestinal Microbiome - drug effects, gut microbiota, Health services, Homeostasis, Immunoglobulins, In vivo methods and tests, Inflammation, Inflammatory bowel disease, Inflammatory bowel diseases, Interleukin 1, Interleukin 6, Intestinal microflora, Intestine, Laboratory animals, Male, Metabolites, Mice, Mice, Inbred ICR, Microbiota, Molecular Structure, Mutagens - pharmacology, Pathogenesis, Peroxidase, Phagocytosis, Phytochemicals, Pretreatment, Prevention, Proteins, short-chain fatty acid, Signs and symptoms, Sodium sulfate, Transmission electron microscopy, Tumor necrosis factor-TNF, Tumor necrosis factor-α, Ulcerative colitis