Virology journal, 2023-11, Vol.20 (1), p.276-276, Article 276
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Susceptibility of bovine to SARS-CoV-2 variants of concern: insights from ACE2, AXL, and NRP1 receptors
- Ist Teil von
- Virology journal, 2023-11, Vol.20 (1), p.276-276, Article 276
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2023
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The possibilities of cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between humans and important livestock species are not yet known. Herein, we used the structural and genetic alignment and surface potential analysis of the amino acid (aa) in angiotensin-converting enzyme 2 (ACE2), tyrosine kinase receptor UFO (AXL), and neuropilin 1 (NRP1) in different species with substantial public health importance. The residues interfacing with the N-terminal domain (NTD) or receptor-binding domain (RBD) of S were aligned to screen the critical aa sites that determined the susceptibility of the SARS-CoV-2 to the host. We found that AXL and NRP1 proteins might be used as the receptors of SARS-CoV-2 in bovines. However, ACE2 protein may not be considered to be involved in the cross-species transmission of SARS-CoV-2 VOCs in cattle because the key residues of the ACE2-S-binding interface were different from those in known susceptible species. This study indicated that emerging SARS-CoV-2 variants potentially expand species tropism to bovines through AXL and NRP1 proteins.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1743-422XeISSN: 1743-422XDOI: 10.1186/s12985-023-02222-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2fc9b7894a434897a83f931ffe954ebe
- Format
- –
- Schlagworte
- ACE2, Amino acids, Analysis, Angiotensin, Angiotensin converting enzyme, Angiotensin-converting enzyme 2, Angiotensin-Converting Enzyme 2 - genetics, Angiotensin-Converting Enzyme 2 - metabolism, Animals, AXL, Axl protein, Beef cattle, Cattle, Coronaviruses, COVID-19, COVID-19 - genetics, COVID-19 - veterinary, Cross-species transmission, Disease susceptibility, Diseases, Enzymes, Health aspects, Livestock, Mutation, Neuropilin, Neuropilin-1 - genetics, Neuropilin-1 - metabolism, NRP1, Peptidyl-dipeptidase A, Physiological aspects, Protein Binding, Protein tyrosine kinase, Protein-tyrosine kinase receptors, Public health, Receptor, Receptors, Virus - genetics, Receptors, Virus - metabolism, SARS-CoV-2 - genetics, SARS-CoV-2 variants, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Species, Spike Glycoprotein, Coronavirus - chemistry, Tropism, Zoonoses