International journal of molecular sciences, 2020-09, Vol.21 (18), p.6634
2020
Details
- Autor(en) / Beteiligte
- Titel
- Effects of Early Life Stress on Bone Homeostasis in Mice and Humans
- Ist Teil von
- International journal of molecular sciences, 2020-09, Vol.21 (18), p.6634
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21186634Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2f6c05fcd85a44b8be4e0aba35cdef76
- Format
- –
- Schlagworte
- Absorptiometry, Photon, Abuse, Adverse Childhood Experiences, Animals, Biomedical materials, Body weight, Bone and Bones - diagnostic imaging, Bone and Bones - innervation, Bone and Bones - metabolism, Bone Density, Bone diseases, Bone mineral density, bone pathologies, Bone turnover, childhood, Children, Collagen, Collagen Type I - blood, Computer architecture, Depressive Disorder - blood, Depressive Disorder - diagnostic imaging, Dual energy X-ray absorptiometry, Extracellular matrix, Female, Gene expression, Growth factors, Homeostasis, Humans, Innervation, Male, Metabolism, Mice, Inbred C57BL, Nerve growth factor, neuroendocrine, Neuropeptides, Osteocalcin, Osteocalcin - blood, Osteoporosis, Peptide Fragments - blood, Peptides, Peptides - blood, Procollagen - blood, psychosocial stress, Retrospective Studies, Risk analysis, Risk factors, Serum levels, Stress response, X-Ray Microtomography