Details

Autor(en) / Beteiligte

• Baker, Kate S.
• Dallman, Timothy J.
• Field, Nigel
• Childs, Tristan
• Mitchell, Holly
• Day, Martin
• Weill, François-Xavier
• Lefèvre, Sophie
• Tourdjman, Mathieu
• Hughes, Gwenda
• Jenkins, Claire
• Thomson, Nicholas

Titel

Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species

Ist Teil von

• Nature communications, 2018-04, Vol.9 (1), p.1462-10, Article 1462

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Horizontal gene transfer has played a role in developing the global public health crisis of antimicrobial resistance (AMR). However, the dynamics of AMR transfer through bacterial populations and its direct impact on human disease is poorly elucidated. Here, we study parallel epidemic emergences of multiple Shigella species, a priority AMR organism, in men who have sex with men to gain insight into AMR emergence and spread. Using genomic epidemiology, we show that repeated horizontal transfer of a single AMR plasmid among Shigella enhanced existing and facilitated new epidemics. These epidemic patterns contrasted with slighter, slower increases in disease caused by organisms with vertically inherited (chromosomally encoded) AMR. This demonstrates that horizontal transfer of AMR directly affects epidemiological outcomes of globally important AMR pathogens and highlights the need for integration of genomic analyses into all areas of AMR research, surveillance and management. Antimicrobial resistance (AMR) in Shigella species is a public health concern. Here, Baker et al. show how horizontal transfer of an AMR plasmid among Shigella species contributes to epidemics in men who have sex with men in England.