Cells (Basel, Switzerland), 2021-04, Vol.10 (4), p.897
2021
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Details
- Autor(en) / Beteiligte
- Titel
- The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases
- Ist Teil von
- Cells (Basel, Switzerland), 2021-04, Vol.10 (4), p.897
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2073-4409eISSN: 2073-4409DOI: 10.3390/cells10040897Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2e3e5cca1c3645c19d057b12e48fca0e
- Format
- –
- Schlagworte
- Acute Lung Injury - immunology, Acute Lung Injury - pathology, acute/chronic inflammatory diseases, Adaptive immunity, Animal models, Animals, Asthma, Asthma - immunology, Asthma - pathology, Chemokines, Chronic Disease, Chronic obstructive pulmonary disease, Collagen, Coronaviridae, Coronaviruses, COVID-19, COVID-19 - immunology, COVID-19 - pathology, Cytokine storm, Cytokines, Fibroblasts, Fibrosis, Genotype & phenotype, Growth factors, Humans, Idiopathic Pulmonary Fibrosis - immunology, Idiopathic Pulmonary Fibrosis - pathology, Immune response, Inflammation, Kinases, Lung - immunology, Lung - pathology, Lung diseases, M1/M2 polarization, Macrophages, Macrophages - immunology, Macrophages - pathology, Mortality, Neutrophils, Obstructive lung disease, Pneumonia - immunology, Pneumonia - pathology, Proteins, Pulmonary Disease, Chronic Obstructive - immunology, Pulmonary Disease, Chronic Obstructive - pathology, Pulmonary fibrosis, Regulation, Respiratory distress syndrome, Respiratory Distress Syndrome - immunology, Respiratory Distress Syndrome - pathology, Review, SARS-CoV-2 - immunology, Severe acute respiratory syndrome coronavirus 2, Transcription activation, Transcription factors, Tumor necrosis factor-TNF