Details

Autor(en) / Beteiligte

• Oliva, Antonio
• Grassi, Simone
• Pinchi, Vilma
• Cazzato, Francesca
• Coll, Mónica
• Alcalde, Mireia
• Vallverdú-Prats, Marta
• Perez-Serra, Alexandra
• Martínez-Barrios, Estefanía
• Cesar, Sergi
• Iglesias, Anna
• Cruzalegui, José
• Hernández, Clara
• Fiol, Victoria
• Arbelo, Elena
• Díez-Escuté, Nuria
• Arena, Vincenzo
• Brugada, Josep
• Sarquella-Brugada, Georgia
• Brugada, Ramon
• Campuzano, Oscar

Titel

Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review

Ist Teil von

• Journal of clinical medicine, 2022-07, Vol.11 (15), p.4406

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.