Details

Autor(en) / Beteiligte

• Cao, Wei
• Lee, Hayan
• Wu, Wei
• Zaman, Aubhishek
• McCorkle, Sean
• Yan, Ming
• Chen, Justin
• Xing, Qinghe
• Sinnott-Armstrong, Nasa
• Xu, Hongen
• Sailani, M Reza
• Tang, Wenxue
• Cui, Yuanbo
• Liu, Jia
• Guan, Hongyan
• Lv, Pengju
• Sun, Xiaoyan
• Sun, Lei
• Han, Pengli
• Lou, Yanan
• Chang, Jing
• Wang, Jinwu
• Gao, Yuchi
• Guo, Jiancheng
• Schenk, Gundolf
• Shain, Alan Hunter
• Biddle, Fred G
• Collisson, Eric
• Snyder, Michael
• Bivona, Trever G

Titel

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Ist Teil von

• Nature communications, 2020-07, Vol.11 (1), p.3675-3675, Article 3675

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome. Hypo-methylated regions are enriched in areas with heterochromatin binding markers (H3K9me3, H3K27me3), while hyper-methylated regions are enriched in polycomb repressive complex (EZH2/SUZ12) recognizing regions. Altered methylation in promoters, enhancers, and gene bodies, as well as in polycomb repressive complex occupancy and CTCF binding sites are associated with cancer-specific gene dysregulation. Epigenetic-mediated activation of non-canonical WNT/β-catenin/MMP signaling and a YY1/lncRNA ESCCAL-1/ribosomal protein network are uncovered and validated as potential novel ESCC driver alterations. This study advances our understanding of how epigenetic landscapes shape cancer pathogenesis and provides a resource for biomarker and target discovery.