Details

Autor(en) / Beteiligte

• Gangaev, Anastasia
• Ketelaars, Steven L C
• Isaeva, Olga I
• Patiwael, Sanne
• Dopler, Anna
• Hoefakker, Kelly
• De Biasi, Sara
• Gibellini, Lara
• Mussini, Cristina
• Guaraldi, Giovanni
• Girardis, Massimo
• Ormeno, Cami M P Talavera
• Hekking, Paul J M
• Lardy, Neubury M
• Toebes, Mireille
• Balderas, Robert
• Schumacher, Ton N
• Ovaa, Huib
• Cossarizza, Andrea
• Kvistborg, Pia

Titel

Identification and characterization of a SARS-CoV-2 specific CD8 + T cell response with immunodominant features

Ist Teil von

• Nature communications, 2021-05, Vol.12 (1), p.2593-2593, Article 2593

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urgent need to map the landscape of immunogenic and immunodominant epitopes recognized by CD8 T cells. Here, we analyze samples from 31 patients with COVID-19 for CD8 T cell recognition of 500 peptide-HLA class I complexes, restricted by 10 common HLA alleles. We identify 18 CD8 T cell recognized SARS-CoV-2 epitopes, including an epitope with immunodominant features derived from ORF1ab and restricted by HLA-A*01:01. In-depth characterization of SARS-CoV-2-specific CD8 T cell responses of patients with acute critical and severe disease reveals high expression of NKG2A, lack of cytokine production and a gene expression profile inhibiting T cell re-activation and migration while sustaining survival. SARS-CoV-2-specific CD8 T cell responses are detectable up to 5 months after recovery from critical and severe disease, and these responses convert from dysfunctional effector to functional memory CD8 T cells during convalescence.