International journal of molecular sciences, 2024-05, Vol.25 (9), p.5015
2024
Details
- Autor(en) / Beteiligte
- Titel
- Metal Toxicity: Effects on Energy Metabolism in Fish
- Ist Teil von
- International journal of molecular sciences, 2024-05, Vol.25 (9), p.5015
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2024
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Metals are dispersed in natural environments, particularly in the aquatic environment, and accumulate, causing adverse effects on aquatic life. Moreover, chronic polymetallic water pollution is a common problem, and the biological effects of exposure to complex mixtures of metals are the most difficult to interpret. In this review, metal toxicity is examined with a focus on its impact on energy metabolism. Mechanisms regulating adenosine triphosphate (ATP) production and reactive oxygen species (ROS) emission are considered in their dual roles in the development of cytotoxicity and cytoprotection, and mitochondria may become target organelles of metal toxicity when the transmembrane potential is reduced below its phosphorylation level. One of the main consequences of metal toxicity is additional energy costs, and the metabolic load can lead to the disruption of oxidative metabolism and enhanced anaerobiosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms25095015Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2a55d1e9dbfc494881c65df324488fb7
- Format
- –
- Schlagworte
- Adenosine triphosphate, Adenosine Triphosphate - metabolism, anaerobic metabolism, Animals, ATP and ROS production, Bioenergetics, Energy, energy metabolism, Energy Metabolism - drug effects, Enzymes, Fishes, Fishes - metabolism, Force and energy, hypoxia, Metabolism, metal toxicity, Metals, Metals - metabolism, Metals - toxicity, Mitochondria, Mitochondria - drug effects, Mitochondria - metabolism, Muscle proteins, Oxidative stress, Oxidative Stress - drug effects, Phosphorylation, Physiological aspects, Physiology, Pollution, Public health, Reactive Oxygen Species - metabolism, Respiration, Toxicity, Water Pollutants, Chemical - toxicity, Water pollution