Details

Autor(en) / Beteiligte

• Mogharbel, Bassam Felipe
• Francisco, Julio Cesar
• Irioda, Ana Carolina
• Dziedzic, Dilcele Silva Moreira
• Ferreira, Priscila Elias
• de Souza, Daiany
• de Souza, Carolina Maria Costa Oliveira
• Neto, Nelson Bergonse
• Guarita-Souza, Luiz Cesar
• Franco, Celia Regina Cavichiolo
• Nakamura, Celso Vataru
• Kaplum, Vanessa
• Mazzarino, Letícia
• Lemos-Senna, Elenara
• Borsali, Redouane
• Soto, Paula A
• Setton-Avruj, Patricia
• Abdelwahid, Eltyeb
• de Carvalho, Katherine Athayde Teixeira

Titel

Fluorescence properties of curcumin-loaded nanoparticles for cell tracking

Ist Teil von

• International journal of nanomedicine, 2018-01, Vol.13, p.5823-5836

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done. Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking. This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.