Details

Autor(en) / Beteiligte

• Costanzo, Giovanni
• Costanzo, Giulia Anna Maria Luigia
• Del Moro, Lorenzo
• Nappi, Emanuele
• Pelaia, Corrado
• Puggioni, Francesca
• Canonica, Giorgio Walter
• Heffler, Enrico
• Paoletti, Giovanni

Titel

Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line

Ist Teil von

• International journal of molecular sciences, 2023-06, Vol.24 (11), p.9771

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Mast cells (MCs) are fascinating cells of the innate immune system involved not only in allergic reaction but also in tissue homeostasis, response to infection, wound healing, protection against kidney injury, the effects of pollution and, in some circumstances, cancer. Indeed, exploring their role in respiratory allergic diseases would give us, perhaps, novel therapy targets. Based on this, there is currently a great demand for therapeutic regimens to enfeeble the damaging impact of MCs in these pathological conditions. Several strategies can accomplish this at different levels in response to MC activation, including targeting individual mediators released by MCs, blockade of receptors for MC-released compounds, inhibition of MC activation, limiting mast cell growth, or inducing mast cell apoptosis. The current work focuses on and summarizes the mast cells' role in pathogenesis and as a personalized treatment target in allergic rhinitis and asthma; even these supposed treatments are still at the preclinical stage.