Toxins, 2019-06, Vol.11 (6), p.321
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis
- Ist Teil von
- Toxins, 2019-06, Vol.11 (6), p.321
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of . This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6651eISSN: 2072-6651DOI: 10.3390/toxins11060321Titel-ID: cdi_doaj_primary_oai_doaj_org_article_278f46d3d74549bc8e86076e7d991860
- Format
- –
- Schlagworte
- Acids, Adaptive Immunity, Antigens, Antiinfectives and antibacterials, Apoptosis, Atopic dermatitis, Bacterial infections, Bacterial Toxins, Cytokines, Dermatitis, Dermatitis, Atopic - immunology, Dermatitis, Atopic - microbiology, Dermatitis, Atopic - therapy, Eczema, enterotoxins, Enzymes, Genotype & phenotype, Gram-positive bacteria, Humans, Immunology, Inflammation, innate immunity, microbiome, Microbiomes, Microbiota, Pathogenesis, Pathogenicity, Pathogens, Proteins, Pruritus, Review, Skin, Skin diseases, Staphylococcal Infections - therapy, Staphylococcus aureus, Toxins, Virulence, Virulence factors