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Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis
Ist Teil von
Toxins, 2019-06, Vol.11 (6), p.321
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2019
Quelle
MEDLINE
Beschreibungen/Notizen
Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of
. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of
superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.