Details

Autor(en) / Beteiligte

• Lv, Bian-Bian
• Yang, Chun-Lan
• Tan, Zhu-Xia
• Zheng, Ling
• Li, Meng-Die
• Jiang, Ya-Lin
• Liu, Ling
• Tang, Min-Min
• Hua, Dong-Xu
• Yang, Jin
• Xu, De-Xiang
• Zhao, Hui
• Fu, Lin

Titel

Association between cadmium exposure and pulmonary function reduction: Potential mediating role of telomere attrition in chronic obstructive pulmonary disease patients

Ist Teil von

• Ecotoxicology and environmental safety, 2023-02, Vol.251, p.114548, Article 114548

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Environmental cadmium (Cd) exposure is linked to pulmonary function injury in the general population. But, the association between blood Cd concentration and pulmonary function has not been investigated thoroughly in chronic obstructive pulmonary disease (COPD) patients, and the potential mechanisms are unclear. All eligible 789 COPD patients were enrolled from Anhui COPD cohort. Blood specimens and clinical information were collected. Pulmonary function test was conducted. The subunit of telomerase, telomerase reverse transcriptase (TERT), was determined through enzyme linked immunosorbent assay (ELISA). Blood Cd was measured via inductively coupled-mass spectrometer (ICP-MS). Blood Cd was negatively and dose-dependently associated with pulmonary function. Each 1-unit increase of blood Cd was associated with 0.861 L decline in FVC, 0.648 L decline in FEV1, 5.938 % decline in FEV1/FVC %, and 22.098 % decline in FEV1 % among COPD patients, respectively. Age, current-smoking, self-cooking and higher smoking amount aggravated Cd-evoked pulmonary function decrease. Additionally, there was an inversely dose-response association between Cd concentration and TERT in COPD patients. Elevated TERT obviously mediated 29.53 %, 37.50 % and 19.48 % of Cd-evoked FVC, FEV1, and FEV1 % declines in COPD patients, respectively. Blood Cd concentration is strongly associated with the decline of pulmonary function and telomerase activity among COPD patients. Telomere attrition partially mediates Cd-induced pulmonary function decline, suggesting an underlying mechanistic role of telomere attrition in pulmonary function decline from Cd exposure in COPD patients. [Display omitted] •Blood cadmium is negatively related to lung function in COPD patients.•Smoking COPD patients with higher BMI are prone to Cd-related lung function decline.•Blood cadmium is inversely related to telomerase activity among COPD patients.•Telomerase activity is positively associated with lung function in COPD patients.•Telomerase activity mediates cadmium-evoked lung function decline in COPD patients.