Details

Autor(en) / Beteiligte

• Ito, Ryoji
• Maruoka, Shuichiro
• Gon, Yasuhiro
• Katano, Ikumi
• Takahashi, Takeshi
• Ito, Mamoru
• Izuhara, Kenji
• Nunomura, Satoshi

Titel

Recent Advances in Allergy Research Using Humanized Mice

Ist Teil von

• International journal of molecular sciences, 2019-06, Vol.20 (11), p.2740

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The prevalence rates of allergic diseases are increasing worldwide, particularly in industrial countries. To date, many mouse models have been generated for allergy research; studies conducted using these models have suggested the importance of cross-talk between immune cells and tissue-resident non-immune cells in the onset of allergic diseases. However, there are several differences between the immune systems of rodents and humans, and human studies are limited. Thus, mice reconstituted with human immune cells are a novel tool for the preclinical evaluation of the efficacy and safety of developing drugs. Genetic technologies for generating humanized mice have improved markedly in recent years. In this review, we will discuss recent progress in allergy research using humanized mice and introduce our recent humanized mouse model of airway inflammation in human immune cells.