Nature communications, 2024-03, Vol.15 (1), p.2790-2790, Article 2790
2024
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Details
- Autor(en) / Beteiligte
- Titel
- FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
- Ist Teil von
- Nature communications, 2024-03, Vol.15 (1), p.2790-2790, Article 2790
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2024
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing. Meanwhile, millions of cell-free DNA samples are being profiled by whole-genome sequencing. Here, we develop FinaleMe, a non-homogeneous Hidden Markov Model, to predict DNA methylation of cell-free DNA and, therefore, tissues-of-origin, directly from plasma whole-genome sequencing. We validate the performance with 80 pairs of deep and shallow-coverage whole-genome sequencing and whole-genome bisulfite sequencing data.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-024-47196-6Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2651db1b0e8b4f7bb0bfb12f96123920
- Format
- –
- Schlagworte
- Biomarkers, Bisulfite, Cancer, Cell-Free Nucleic Acids - genetics, Datasets, Deoxyribonucleic acid, DNA, DNA fragmentation, DNA methylation, DNA Methylation - genetics, DNA sequencing, Genetics, Genomes, High-Throughput Nucleotide Sequencing, Hypotheses, Markov chains, Plasma, Sequence Analysis, DNA - methods, Sulfites, Whole genome sequencing, Whole Genome Sequencing - methods