Details

Autor(en) / Beteiligte

• Lane, Sidney
• White, Tristan L A
• Walsh, Erin E
• Cattley, Richard T
• Cumberland, Rachel
• Hawse, William F
• Delgoffe, Greg M
• Badylak, Stephen F
• Bomberger, Jennifer M
• Parsek, Matthew

Titel

Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections

Ist Teil von

• mBio, 2023-10, Vol.14 (5), p.e0086323

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2023

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Miscommunication of antiviral and antibacterial immune signals drives worsened morbidity and mortality during respiratory viral-bacterial coinfections. Extracellular vesicles (EVs) are a form of intercellular communication with broad implications during infection, and here we show that epithelium-derived EVs released during the antiviral response impair the antibacterial activity of macrophages, an innate immune cell crucial for bacterial control in the airway. Macrophages exposed to antiviral EVs display reduced clearance of as well as altered inflammatory signaling and anti-inflammatory metabolic reprogramming, thus revealing EVs as a source of dysregulated epithelium-macrophage crosstalk during coinfection. As effective epithelium-macrophage communication is critical in mounting an appropriate immune response, this novel observation of epithelium-macrophage crosstalk shaping macrophage metabolism and antimicrobial function provides exciting new insight and improves our understanding of immune dysfunction during respiratory coinfections.