Details

Autor(en) / Beteiligte

• Mancini, Shelby L
• Early, Peter J
• Pastina, Bethany O
• Olby, Natasha J
• Mariani, Christopher L
• Munana, Karen R

Titel

The bioavailability of cytarabine in dogs with meningoencephalitis of unknown etiology through iontophoresis and rectal delivery

Ist Teil von

• Open veterinary journal (Tripoli, Libya), 2021-01, Vol.11 (1), p.36-38

Ort / Verlag

Libya: Faculty of Veterinary Medicine

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Cytarabine (CA) is used to treat dogs with meningoencephalitis of unknown etiology (MUE) by subcutaneous or intravenous administration. The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery. Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGO™ 12.0 iontophoresis drug delivery system delivered 200 mg/m2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography. The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1 μg/ml) in all samples suggesting inadequate bioavailability with transdermal and rectal administration. Transdermal and rectal CA administration are not reasonable alternative routes of delivery.