Details

Autor(en) / Beteiligte

• Chu, Hongxing
• Li, Zhengqiang
• Gan, Zekun
• Yang, Zinan
• Wu, Zhenzhen
• Rong, Mingdeng

Titel

LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism

Ist Teil von

• OncoTargets and therapy, 2019-08, Vol.12, p.6857-6863

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The present study aims to investigate the role of ELF3-AS1 in oral squamous cell carcinoma (OSCC). A total of 112 patients with OSCC were admitted in Guangdong Provincial Stomatological Hospital from March 2016 to March 2019. RT-qPCR, cells and transient transfections, cell proliferation rate measurements and Western blots were carried out to analyze the samples. In the present study, we showed that ELF3-AS1 and glucose transporter 1 (GLUT1) were both upregulated in OSCC tissues, and those two factors were positively correlated. In OSCC cells, ELF3-AS1 overexpression resulted in upregulation, while ELF3-AS1 siRNA silencing caused downregulated expression of GLUT1 and glucose uptake. ELF3-AS1 and GLUT1 overexpression resulted in increased rate of OSCC cells, while ELF3-AS1 and GLUT1 siRNA silencing resulted in decreased proliferation rate of OSCC cells. In addition, GLUT1 siRNA silencing attenuated the effects of ELF3-AS1 overexpression. Therefore, ELF3-AS1 promotes the proliferation of OSCC cells by reprogramming glucose metabolism.