International journal of molecular sciences, 2019-09, Vol.20 (19), p.4827
2019
Details
- Autor(en) / Beteiligte
- Titel
- Selecting an Appropriate Animal Model of Depression
- Ist Teil von
- International journal of molecular sciences, 2019-09, Vol.20 (19), p.4827
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms20194827Titel-ID: cdi_doaj_primary_oai_doaj_org_article_24dc1838318046a59855e627a8b3ba55
- Format
- –
- Schlagworte
- animal model, Animal models, Animals, Antidepressants, Antioxidants, behavior test, Behavior, Animal, Brain, Brain-derived neurotrophic factor, depression, Depression - etiology, Depression - psychology, Depressive Disorder - etiology, Depressive Disorder - psychology, Disease Models, Animal, Humans, Mental depression, Mental disorders, Molecular modelling, Morphology, Oxidative stress, Review, Suicides & suicide attempts, Validation studies, Validity