Details

Autor(en) / Beteiligte

• Figueiredo, Indyra Alencar Duarte
• Ferreira, Sarah Rebeca Dantas
• Fernandes, Jayne Muniz
• Silva, Bagnólia Araújo da
• Vasconcelos, Luiz Henrique César
• Cavalcante, Fabiana de Andrade

Titel

A review of the pathophysiology and the role of ion channels on bronchial asthma

Ist Teil von

• Frontiers in pharmacology, 2023-09, Vol.14, p.1236550-1236550

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Asthma is one of the main non-communicable chronic diseases and affects a huge portion of the population. It is a multifactorial disease, classified into several phenotypes, being the allergic the most frequent. The pathophysiological mechanism of asthma involves a Th2-type immune response, with high concentrations of allergen-specific immunoglobulin E, eosinophilia, hyperreactivity and airway remodeling. These mechanisms are orchestrated by intracellular signaling from effector cells, such as lymphocytes and eosinophils. Ion channels play a fundamental role in maintaining the inflammatory response on asthma. In particular, transient receptor potential (TRP), stock-operated Ca 2+ channels (SOCs), Ca 2+ -activated K + channels (IK Ca and BK Ca ), calcium-activated chloride channel (TMEM16A), cystic fibrosis transmembrane conductance regulator (CFTR), piezo-type mechanosensitive ion channel component 1 (PIEZO1) and purinergic P2X receptor (P2X). The recognition of the participation of these channels in the pathological process of asthma is important, as they become pharmacological targets for the discovery of new drugs and/or pharmacological tools that effectively help the pharmacotherapeutic follow-up of this disease, as well as the more specific mechanisms involved in worsening asthma.